Depression is one of the most common emotional reactions following brain injury and can occur when the ABI survivor gains more insight into their long-term limitations. With this insight comes the realisation of the losses that they have had – physically, psychologically and socially – and that life will not be as it was. They may feel inadequate or guilty if they cannot fulfill their previous role, e.g. as a breadwinner. This change in role may also result in a loss of self-esteem. A person may have to come to terms with losing their partner, be unable to pursue former leisure activities or they may have to abandon former career plans. Depression is a normal reaction to loss for all of us, though in many ways it can be considered as a sign of recovery as it indicates that the person recognises their new circumstances. This is essential to the success of continuing rehabilitation and the realisation of a person’s full potential.